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TLS Online TPP Program

#Id: 6679

SR proteins are involved in exon definition in which they interact with U1 and U2AF forming commitment E complex.


#Unit 3. Fundamental Processes #Capping, Polyadenylation, Splicing and Alternative splicing #Part B Pointers
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TLS Online TPP Program

#Id: 8846

#Unit 2. Cellular Organization

In budding yeast CKI p27 = Sic1 in metazoans
TLS Online TPP Program

#Id: 8847

#Unit 2. Cellular Organization

When CDK activity is low= helicases are loaded in G1
When CDK activity is high= helicases are activated in
S, G2 & M
TLS Online TPP Program

#Id: 8848

#Unit 2. Cellular Organization
TLS Online TPP Program

#Id: 8849

#Unit 2. Cellular Organization

Phosphorylation of MCM helicase activators by G1/S phase CDKs and S phase CDKs, prevents reloading of MCM helicases (ensuring that replication from each origin occurs only once during each cell cycle)
TLS Online TPP Program

#Id: 8850

#Unit 2. Cellular Organization

Geminin 
a small protein,, that contributes to the inhibition of re-initiation at origins until cells complete a full cell cycle.
TLS Online TPP Program

#Id: 8851

#Unit 2. Cellular Organization

Geminin is expressed in late G1; it binds to and inhibits Cdt1 preventing reloading of the MCM helicase.