As a result of their modest telomerase activity, their telomeres shorten with each cell cycle.

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#Id: 2767

#Unit 13. Methods in Biology

We perform DNase footprinting by binding the protein to its DNA target, then digesting the DNA–protein complex with DNase. 

When we electrophorese the resulting DNA fragments, the protein binding site shows up as a gap, or “footprint,” in the pattern where the protein protected the 

DNA from degradation.

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#Id: 7414

#Unit 5. Developmental Biology

The homologue of β-catenin in Drosophila is Armadillo.

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#Id: 8159

#Unit 2. Cellular Organization

KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER

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#Id: 10476

#Unit 4. Cell Communication and Cell Signaling

Inherited a single mutant NF1 allele then develop neurofibromas, a benign tumor of the sheath cells that surround nerves, caused by loss of both alleles through LOH.

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#Id: 10455

#Unit 4. Cell Communication and Cell Signaling

Chronic myelogenous leukemia, 

a common leukemia in humans, associated with the Philadelphia chromosome