Shelterin functions to protect telomeres from DNA damage repair pathways and to regulate telomere length control by telomerase

TLS Online TPP Program

#Id: 669

#Unit 3. Fundamental Processes

As a result of their modest telomerase activity, their telomeres shorten with each cell cycle.

TLS Online TPP Program

#Id: 670

#Unit 3. Fundamental Processes

Extensive shortening of telomeres is recognized by the cell as a double-strand break and consequently triggers cell cycle arrest and apoptosis.

TLS Online TPP Program

#Id: 671

#Unit 3. Fundamental Processes

In mammals, six telomeric proteins (TRF1, TRF2, Rap1, TIN2, TPP1, and POT1) comprise a complex called shelterin

TLS Online TPP Program

#Id: 672

#Unit 3. Fundamental Processes

Duplex telomeric DNA interactions of TRF1 and TRF2 and the binding of POT1 to the single-stranded TTAGGG repeats.

TLS Online TPP Program

#Id: 674

#Unit 3. Fundamental Processes

The telomerase uses the 3’–OH of the G+T telomeric strand as a primer for synthesis of tandem TTGGGG repeats.

 

TLS Online TPP Program

#Id: 675

#Unit 3. Fundamental Processes

For the synthesis of telomere, Only dGTP and dTTP are needed for the activity.