Cytoplasmic mRNAs are degraded by one of the three pathways. For most mRNAs, the deadenylation-dependent pathway is followed These dense regions of cytoplasm contain the decapping enzyme (DCP1/DCP2), activators of decapping (DHH, PAT1, LSM1-7), and the major 5′→3′ exoribonuclease XRN1, as well as densely associated mRNAs

TLS Online TPP Program

#Id: 1699

#Unit 4. Cell Communication and Cell Signaling

Granulocytes

1. Neutrophils

2. Basophils

3. Mast cells

4. Eosinophils

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#Id: 1700

#Unit 4. Cell Communication and Cell Signaling

Granulocytes can be seen by FACS.

TLS Online TPP Program

#Id: 1701

#Unit 4. Cell Communication and Cell Signaling

Neutrophils constitute the majority (50% to 70%) of circulating leukocytes Eosinophils (1%–3%), Basophils (1%), or Mast cells (1%).

TLS Online TPP Program

#Id: 1702

#Unit 4. Cell Communication and Cell Signaling

The resulting transient increase in the number of circulating neutrophils, called leukocytosis.

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#Id: 1703

#Unit 4. Cell Communication and Cell Signaling

Neutrophils phagocytose (engulf) bacteria very effectively, and also secrete a range of proteins that have antimicrobial effects and tissue remodeling potential.

TLS Online TPP Program

#Id: 1704

#Unit 4. Cell Communication and Cell Signaling

Neutrophils- First cell against infection