When the 5′ end of the siRNA of a RISC complex base-pairs precisely with a target mRNA over a distance of one turn of an RNA helix (10–12 base pairs), this domain of AGO2 cleaves the phosphodiester bond of the target RNA across from nucleotides 10 and 11 of the siRNA

TLS Online TPP Program

#Id: 8179

#Unit 2. Cellular Organization

Peroxisomes contain oxidative enzymes: catalase and urate oxidase.

TLS Online TPP Program

#Id: 8180

#Unit 2. Cellular Organization

Peroxisomes carry out oxidation reactions leading to the production of hydrogen peroxide.

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#Id: 8181

#Unit 2. Cellular Organization

Catalase uses the H2O2 to oxidize a variety of other substrates (formic acid, formaldehyde, and alcohol) by the “peroxidation” reaction.

TLS Online TPP Program

#Id: 8182

#Unit 2. Cellular Organization

When excess H2O2 accumulates in the cell, catalase converts it to H2O through the reaction.

TLS Online TPP Program

#Id: 8183

#Unit 2. Cellular Organization

β oxidation 

A major function of the oxidation reactions is the breakdown of fatty acid molecules.

TLS Online TPP Program

#Id: 8184

#Unit 2. Cellular Organization

β oxidation

In mammalian cells, occurs in mitochondria & peroxisomes.

In yeast and plant cells, occurs in peroxisomes.