There are two de novo methyltransferases (Dnmt3A and Dnmt3B) in the mouse; they have different target sites, and both are essential for development.

TLS Online TPP Program

#Id: 1731

#Unit 4. Cell Communication and Cell Signaling

FcεRI signalling through Lyn and Syk kinases also activates E3 ubiquitin ligases, including c-Cbl. Cbl ubiquitinylates Lyn and Syk, as well as FcεRI itself, triggering their degradation.

TLS Online TPP Program

#Id: 1732

#Unit 4. Cell Communication and Cell Signaling

The early response occurs within minutes of allergen exposure and results from the release of histamine, leukotrienes, and prostaglandins from local mast cells.

TLS Online TPP Program

#Id: 1733

#Unit 4. Cell Communication and Cell Signaling

Eosinophils play a principal role in the late-phase reaction.

TLS Online TPP Program

#Id: 1734

#Unit 4. Cell Communication and Cell Signaling

There Are Several Categories of Type I Hypersensitivity Reactions

1. Systemic Anaphylaxis

2. Localized Hypersensitivity Reactions

TLS Online TPP Program

#Id: 1735

#Unit 4. Cell Communication and Cell Signaling

Diagnostic approach

1. Skin testing

2. Measure the serum levels of either total or allergen specific IgE using ELISA or Western blot technologies

TLS Online TPP Program

#Id: 1736

#Unit 4. Cell Communication and Cell Signaling

Antigen pieces are held within the binding groove of a cell surface protein called the major histocompatibility complex (MHC) molecule which recognized by T cell