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TLS Online TPP Program

#Id: 6940

An inversion may break a gene into two parts, with one part moving to a new location and destroying the function of that gene.



#Unit 8. Inheritance Biology #Structural and numerical alterations of chromosomes #Part B Pointers
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TLS Online TPP Program

#Id: 570

#Unit 2. Cellular Organization

The lac operator is 21-bp sequence with twofold symmetric and is recognized by two subunits of Lac repressor
 
TLS Online TPP Program

#Id: 571

#Unit 2. Cellular Organization

Constitutive mutations occur at 8 positions in the operator between +5 and +17 called OC
TLS Online TPP Program

#Id: 572

#Unit 2. Cellular Organization

Repressor binds with O1and O3 tonhibit expression of lacZ
TLS Online TPP Program

#Id: 573

#Unit 2. Cellular Organization

Effects of mutations in the three lac operators
All three operators are essential for effective repression.
TLS Online TPP Program

#Id: 574

#Unit 2. Cellular Organization

OC are constitutive because repressor protein is unable to bind; this allows RNA polymerase to have unrestrained access to the promoter. 
TLS Online TPP Program

#Id: 575

#Unit 2. Cellular Organization

The Oc mutations are cis-acting/cis dominant, because they affect only the contiguous set of structural genes.