If their positions are altered by an inversion, their expression may be altered, an outcome referred to as a position effect.

TLS Online TPP Program

#Id: 6895

#Unit 3. Fundamental Processes

UHRF1, that is important for the maintenance of methylation both locally and globally through its association with Dnmt1.

TLS Online TPP Program

#Id: 6896

#Unit 3. Fundamental Processes

UHRF1 also interacts with methylated histone H3, which connects the maintenance of DNA methylation with the stabilization of heterochromatin structure

TLS Online TPP Program

#Id: 6897

#Unit 3. Fundamental Processes

HP1 is recruited to regions in which histone H3 has been methylated at lysine 9, a modification involved in heterochromatin formation. It turns out that HP1 can also interact with Dnmt1, which can promote DNA methylation in the vicinity of HP1 binding. Furthermore, Dnmt1 can directly interact with the methyltransferase responsible for H3K9 methylation, creating a positive feedback loop to ensure continued DNA and histone methylation.

TLS Online TPP Program

#Id: 6898

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6899

#Unit 3. Fundamental Processes

5-hydroxymethylcytosine (5hmC) is now novel epigenetic marks. The “teneleven translocation 1-3” or Tet1-3 proteinsare DNA TET hydroxylase enzymes that can convert 5mC to 5hmC, and can further convert 5hmC to 5-formylcytosine (5fC) and then 5- carboxylcytosine (5caC) in successive reactions.

TLS Online TPP Program

#Id: 6900

#Unit 3. Fundamental Processes

5-hydroxymethylcytosine (5hmC) is now novel epigenetic marks. The “teneleven traProteins that normally recognize 5mC, such as MeCP2, do not bind to 5hmC, suggesting that generation of 5hmC might serve to reverse methylation-dependent silencing.