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TLS Online TPP Program

#Id: 7011

Regulation is highly influenced by the microenvironment that surrounds a stem cell and is known as the stem cell niche.


#Unit 5. Developmental Biology #Basic concepts of development #Part B Pointers
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TLS Online TPP Program

#Id: 9467

#Unit 4. Cell Communication and Cell Signaling

SH2 domain of STAT binds to a specific phosphotyrosine in the cytosolic domain of an activated receptor
TLS Online TPP Program

#Id: 9468

#Unit 4. Cell Communication and Cell Signaling

Erythropoietin receptor & the receptors for GH, prolactin, G-CSF, activates STAT5 but not STATs 1, 2, 3, or 4. 
TLS Online TPP Program

#Id: 9469

#Unit 4. Cell Communication and Cell Signaling

IL-2 receptor complex activates
STATs 1, 3, and 5 but not STATs 2 or 4
TLS Online TPP Program

#Id: 9470

#Unit 4. Cell Communication and Cell Signaling

Phosphorylated STAT dissociates spontaneously from the receptor, and two phosphorylated STAT proteins form a homodimer.
TLS Online TPP Program

#Id: 9471

#Unit 4. Cell Communication and Cell Signaling

STAT5 becomes activated in erythroid progenitor cells and induces expression of the protein Bcl-xL.
TLS Online TPP Program

#Id: 9472

#Unit 4. Cell Communication and Cell Signaling

Two mechanisms for terminating cytokine signaling:
1. Short-term regulation: SHP1
2. Long-term regulation: SOCS proteins