In the presence of brassinolide, the activated phosphatase BSU1 dephosphorylates BIN2 and promotes its degradation by the 26S proteasome system, thus blocking its activity. BES1 and BZR1 are then dephosphorylated by PROTEIN PHOSPHATASE2A (PP2A), and the active forms of BES1 and BZR1 move into the nucleus where they regulate the expression of brassinolide response genes

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#Unit 4. Cell Communication and Cell Signaling

T2 cells also express BAFF-R, the receptor for the B-cell survival factor BAFF, whose expression is dependent on signals received through the BCR.

As B cells differentiate from the transitional T2 state to full maturity, they raise their levels of mIgD still further, while reducing the expression of mIgM. They also cease to express CD24 and CD93.

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#Unit 4. Cell Communication and Cell Signaling

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#Id: 1915

#Unit 4. Cell Communication and Cell Signaling

T-dependent (TD) response

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#Unit 4. Cell Communication and Cell Signaling

T-independent response

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#Unit 4. Cell Communication and Cell Signaling

B-Cell Activation

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#Unit 4. Cell Communication and Cell Signaling

Generation of antibodies to T-dependent antigens