TLS Online TPP Program

#Id: 1578

#Unit 4. Cell Communication and Cell Signaling

Active Wnt signaling leads to the secretion of Notum.

 

TLS Online TPP Program

#Id: 1579

#Unit 4. Cell Communication and Cell Signaling

Notum, a hydrolase that associates with glypican and then cleaves off Wnt’s attached lipids in a process of deacylation or delipidation.

TLS Online TPP Program

#Id: 1580

#Unit 4. Cell Communication and Cell Signaling

Delipidation process reduces Wnt signaling, creates a negative feedback mechanism for preventing excessive Wnt signaling.

TLS Online TPP Program

#Id: 1581

#Unit 4. Cell Communication and Cell Signaling

Frizzled receptor possesses a unique hydrophobic cleft adapted to interact with lipidated Wnts, a binding conformation mimicked in Notum’s structure as well.

  

TLS Online TPP Program

#Id: 1582

#Unit 4. Cell Communication and Cell Signaling

Antagonists of Wnt:

Secreted frizzled-related protein (Sfrp)

Wnt inhibitory factor (Wif)

Dickkopf (Dkk) family

TLS Online TPP Program

#Id: 1475

#Unit 4. Cell Communication and Cell Signaling

25 percent of acute myeloid leukemias are characterized by DNA hypomethylation that is due to inactivating mutations in an enzyme that catalyzes the methylation of CpG dinucleotides.