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TLS Online TPP Program

#Id: 7472


The two β pleated sheets in each domain are held together by hydrophobic interactions and the conserved disulfide bond.  The three loops of each variable domain show considerable variation in length and amino acid sequence; these hyper variable regions  make up the antigen-binding site. 



#Unit 4. Cell Communication and Cell Signaling #Antibody #Part B Pointers
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TLS Online TPP Program

#Id: 8334

#Unit 2. Cellular Organization

Phalloidin 
isolated from Amanita phalloides, binds at the interface between subunits in F-actin, locking adjacent subunits together and preventing depolymerization.

TLS Online TPP Program

#Id: 8335

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8336

#Unit 2. Cellular Organization

Actin filament treadmilling is accelerated by:

Profilin and Cofilin

TLS Online TPP Program

#Id: 8337

#Unit 2. Cellular Organization

Profilin – G-actin nucleotide exchange (ADP to ATP) 
Cofilin – F-actin disassembly
Thymosin B-4 – G-actin monomer sequestering

TLS Online TPP Program

#Id: 8338

#Unit 2. Cellular Organization

Profilin can bind proteins with sequences rich in proline residues at the same time it is bound to actin.

TLS Online TPP Program

#Id: 8339

#Unit 2. Cellular Organization

Filament capping proteins:

CapZ blocks (+)end Tropomodulin blocks (-)end


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