IgG efficiently opsonizes pathogens for engulfment by phagocytes and activates the complement system. The affinity of the individual antigen binding sites for their antigen is therefore critical for the effectiveness of these antibodies, and most of the B cells expressing these classes have been selected in the germinal centers for their increased affinity for antigen after somatic hyper mutation.
#Unit 4. Cell Communication and Cell Signaling#Antibody#Part B Pointers
