TIR1 recruits AUX/ IAA proteins to the SCF -TIR1 complex in an auxin-dependent manner. Once recruited by auxin, AUX/IAA proteins are ubiquitinated by the E3 ligase activity of the SCF-TIR1 complex, which marks the protein for destruction by the 26S proteasome.

TLS Online TPP Program

#Id: 8765

#Unit 1. Molecules and their Interaction Relevant to Biology

Disulfide bonds are believed to increase the stability of the native state by decreasing the conformational entropy of the unfolded state due to the conformational constraints imposed by cross-linking (i. e. decreasing the free energy of the unfolded state).  

TLS Online TPP Program

#Id: 8766

#Unit 1. Molecules and their Interaction Relevant to Biology

Most protein have "loops" introduced by disulfides of about 15 residues

TLS Online TPP Program

#Id: 8767

#Unit 1. Molecules and their Interaction Relevant to Biology

Guanidinium ion and urea are chaotropic agents which disrupts hydrophobic core of proteins.

TLS Online TPP Program

#Id: 8768

#Unit 1. Molecules and their Interaction Relevant to Biology

TLS Online TPP Program

#Id: 8769

#Unit 1. Molecules and their Interaction Relevant to Biology

TLS Online TPP Program

#Id: 8770

#Unit 1. Molecules and their Interaction Relevant to Biology