The influx of bicarbonate ions (and possibly other ions) alkalinizes the sperm, raising its pH. This will be critical in the subsequent activation of calcium channels

TLS Online TPP Program

#Id: 881

#Unit 13. Methods in Biology

Most STRs are found in the noncoding regions, while only about 8% locate in the coding regions.

TLS Online TPP Program

#Id: 882

#Unit 13. Methods in Biology

The genetic diseases caused by trinucleotide repeat SSRs within genes. Huntington disease (HD) is one of the approximately 20 such trinucleotide repeat diseases in humans. HD is transmitted as an autosomal dominant mutation.

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#Id: 883

#Unit 13. Methods in Biology

In humans, chromosome 19 has the highest density of STRs. Disease associated with SSR are called as Repeat expansion diseases.

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#Id: 884

#Unit 13. Methods in Biology

Most common cause of Repeat expansion is SLIPPAGE during replications.

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#Id: 885

#Unit 13. Methods in Biology

On average, one STR occurs per 2,000 bp in the human genome.

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#Id: 886

#Unit 13. Methods in Biology

The most common STRs in humans are A-rich units: A, AC, AAAN, AAN, and AG. The STR locus is named as, for example, D3S1266, where D represents DNA, 3 means chromosome 3 on which the STR locus locates, S stands for STR, and 1266 is the unique identifier.