bab Motif

These motifs are generally found in right handed helix above the plane of the beta sheet

Almost all the proteins containing parallel beta sheets have this motif. 

The helix is generally not seen below the plane of beta sheets                                           

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#Unit 7. System Physiology – Animal

Process of concentrating the iodide in the cell is called iodide trapping

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#Unit 7. System Physiology – Animal

Na+/I – symporter (NIS) is capable of producing intracellular I – concentrations that are 20– 40 times as great as the concentration in plasma

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#Unit 7. System Physiology – Animal

Wolff –Chaikoff effect large doses of iodide act directly on the thyroid to produce a mild and transient inhibition of organic binding of iodide and hence of hormone synthesis.

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#Unit 7. System Physiology – Animal

Thyroid stimulating hormone induces both NIS expression and the retention of NIS in the basolateral membrane.

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#Unit 7. System Physiology – Animal

Iodide is transported out of the thyroid cells across the apical membrane into the follicle by a chloride-iodide ion counter- transporter molecule called pendrin.

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#Unit 7. System Physiology – Animal

Thyroglobulin is a glycoprotein contains 123 tyrosine residues, but only 4–8 of these are normally incorporated into thyroid hormones.