aa motif / Coiled-coils

Two helices are wound around each other

Alpha-helices are packed together through the hydrophobic interactions

These two helices are found to be stable in solution

They are generally found in transcription factors and intermediate filaments

They have heptad (7 amino acid) repeated sequences


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#Unit 8. Inheritance Biology

Chromosome deletion 

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#Unit 8. Inheritance Biology

Chromosome deletion - Loss of a chromosome segment.

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#Id: 6920

#Unit 8. Inheritance Biology

Deletion include,
Terminal deletion

ntercalary/interstitial deletion 

Microdeletion

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#Id: 6921

#Unit 8. Inheritance Biology

Cri-du- chat syndrome- Deletion on 5, short arm

Wolf– Hirschhorn syndrome- Deletion on 4, short arm

Williams– Beuren syndrome - Deletion on 7, long arm

Prader– Willi syndrome- Deletion on 15 long arm 

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#Unit 8. Inheritance Biology

Deletion of a number of pairs that is not evenly divisible by three will lead to a frameshift mutation. 

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#Unit 8. Inheritance Biology

In an individual heterozygous for a deletion, the normal chromosome loops out during chromosome pairing in prophase I.