aa motif / Coiled-coils

Two helices are wound around each other

Alpha-helices are packed together through the hydrophobic interactions

These two helices are found to be stable in solution

They are generally found in transcription factors and intermediate filaments

They have heptad (7 amino acid) repeated sequences


TLS Online TPP Program

#Id: 2762

#Unit 13. Methods in Biology

Lane 3 depicts the behavior of the same DNA bound to two proteins. The mobility is reduced still further because of the greater mass of protein clinging to the DNA. This is 

called a supershift. 

TLS Online TPP Program

#Id: 7883

#Unit 2. Cellular Organization

MICOS function as a diffusion barrier to prevent mixing of the distinct proteins and lipids in the boundary membrane and crista membranes.

TLS Online TPP Program

#Id: 5890

#Unit 3. Fundamental Processes

In DNA polymerase, the nucleotide-binding pocket cannot accommodate a 2’-OH on the in-coming nucleotide. This space is occupied by two amino acids that make van der Waals contacts with the sugar ring. Changing these amino acids to other amino acids with 

TLS Online TPP Program

#Id: 3261

#Unit 3. Fundamental Processes

g-radiation and X-rays (ionizing radiation) are particularly hazardous because they cause double-strand breaks in the DNA, which are difficult to repair. If left unrepaired, double-strand breaks can be lethal to a cell.

TLS Online TPP Program

#Id: 506

#Unit 2. Cellular Organization

The rate of loss of single-stranded (ss) DNA during renaturation is a second-order rate process