Two sugars that differ in configuration at only one chiral center are described as epimers.

TLS Online TPP Program

#Id: 8866

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8867

#Unit 2. Cellular Organization

Cdc25B is act as a starter phosphatase that initiates CDK1 activation

Cdc25C is the workhorse phosphatase that activates the vast majority of cyclin-CDK1 complexes

TLS Online TPP Program

#Id: 8868

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8869

#Unit 2. Cellular Organization

Yeast cells with a defective wee1+ gene activate mitotic CDKs prematurely and premature entry into mitosis (smaller than normal cells

TLS Online TPP Program

#Id: 8870

#Unit 2. Cellular Organization

Fission yeast cells carrying a CDK1 mutation in which the tyrosine-15 residue is replaced by phenylalanine

show the same premature mitotic CDK activation and entry into mitosis.

TLS Online TPP Program

#Id: 8871

#Unit 2. Cellular Organization

Until Mitotic CDKs is not active, the activatory protein phosphatase, Cdc25, is phosphorylated, bound and inhibited by phosphoserine/threonine-binding protein 14-3-3.