The majority of proteins located in mitochondria are not encoded by mtDNA, they are encoded by genes in the nucleus and are imported into the mitochondria after their synthesis in the cytosol.

TLS Online TPP Program

#Id: 8192

#Unit 2. Cellular Organization

Catalase, are synthesized as precursors with PTS1

Thiolase, are synthesized as precursors with PTS2

TLS Online TPP Program

#Id: 8193

#Unit 2. Cellular Organization

Pex5 forms a multimeric complex with the Pex14 receptor located on the peroxisomal membrane. 

TLS Online TPP Program

#Id: 8194

#Unit 2. Cellular Organization

After assembly of the matrix protein-Pex5-Pex14 complex, the matrix protein dissociates from Pex5 and is released into the peroxisomal matrix.

TLS Online TPP Program

#Id: 8195

#Unit 2. Cellular Organization

A Pex 2, Pex 10, and Pex 12 complex embedded in the peroxisomal membrane transfers Ubiquitin to two embedded Pex 5 receptors.

TLS Online TPP Program

#Id: 8196

#Unit 2. Cellular Organization

The AAA ATPases Pex1 and Pex6 complex use the energy from ATP hydrolysis and causing the detachment of Pex 5 receptors into cytosol.

TLS Online TPP Program

#Id: 8197

#Unit 2. Cellular Organization

Zellweger syndrome

Autosomal recessive Mutations in any of a dozen different peroxins, the most common being Pex1, cause an impairment in peroxisomal protein import.