The SRP is a cytosolic ribonucleoprotein particle that transiently binds to both the ER signal sequence in a nascent protein and the large (60S) ribosomal subunit, forming a large complex.

TLS Online TPP Program

#Id: 5798

#Unit 7. System Physiology – Animal

The thyroid hormone receptor usually forms a heterodimer with retinoid X receptor (RXR) at specific thyroid hormone response elements on the DNA

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#Id: 5799

#Unit 7. System Physiology – Animal

TLS Online TPP Program

#Id: 5800

#Unit 7. System Physiology – Animal

Thyrotropin-releasing hormone (TRH) Tripeptide (amide—pyroglutamyl-histidylproline-amide) Stimulates secretion of TSH by thyrotropes

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#Id: 5801

#Unit 7. System Physiology – Animal

TRH receptors in the pituitary cell membrane activates the phospholipase second messenger system, leads to TSH release.

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#Id: 5802

#Unit 7. System Physiology – Animal

TSH(thyrotropin)

Increased proteolysis of the thyroglobulin Increased activity of the iodide pump Increased iodination of tyrosine

Increased size and increased secretory activity of the thyroid cells

Increased number of thyroid cells

TLS Online TPP Program

#Id: 5803

#Unit 7. System Physiology – Animal

Hyperthyroidism Thyrotoxicosis

Graves’ Disease Toxic Goiter