Emphysema caused by a point mutation in -antitrypsin, which is normally secreted by hepatocytes and macrophages.

TLS Online TPP Program

#Id: 6469

#Unit 3. Fundamental Processes

There are 27 of these repeats in the yeast Pol II CTD, 32 in the worm Caenorhabditis elegans, 45 in the fly Drosophila, and 52 in humans.  YSPTSPS repeats in CTD corresponds to the complexity of the genome.

TLS Online TPP Program

#Id: 6470

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6471

#Unit 3. Fundamental Processes

The RNA polymerase I promoter consists of a core promoter and an upstream promoter element (UPE).

TLS Online TPP Program

#Id: 6472

#Unit 3. Fundamental Processes

RNA polymerase I requires two ancillary transcription factors to recognize the promoter sequence. The factor that binds to the core promoter is SL1 which consists of four protein subunits. SL1 has primary responsibility for RNA polymerase recruitment

TLS Online TPP Program

#Id: 6473

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6474

#Unit 3. Fundamental Processes

The promoters for Classes I and II, 5S and tRNA genes, are internal; they lie downstream of the start point.