The holoenzyme could transcribe intact phage T4 DNA in vitro quite actively, the core enzyme had little ability to do this.

TLS Online TPP Program

#Id: 8645

#Unit 2. Cellular Organization

Rb protein regulation by G1 CDKs in mammalian cells is analogous to Whi5 regulation by Cln3-CDK in yeast.

TLS Online TPP Program

#Id: 8646

#Unit 2. Cellular Organization

One of the important substrates of the G1/S phase cyclin-CDK complexes is Cdh1.

TLS Online TPP Program

#Id: 8647

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8648

#Unit 2. Cellular Organization

During exit from mitosis and G1, 

Cdh1 is de-phosphorylated and APC/Ccdh1 is active.

TLS Online TPP Program

#Id: 8649

#Unit 2. Cellular Organization

During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

TLS Online TPP Program

#Id: 8650

#Unit 2. Cellular Organization

G1/S phase CDKs phosphorylate Cdh1 at the 

G1-S phase transition