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TLS Online TPP Program

#Id: 8101

In cardiolipin, two phosphatidic acids share a single glycerol (R1 and R2 are fatty acyl groups).


#Unit 1. Molecules and their Interaction Relevant to Biology #Lipid #Part B Pointers
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TLS Online TPP Program

#Id: 426

#Unit 2. Cellular Organization

Heterochromatin generally maintains 10,000-fold compaction in both interphase and mitosis after 30 nm.
TLS Online TPP Program

#Id: 427

#Unit 2. Cellular Organization

Chromatin contains DNA, Histones, Nonhistone Proteins and RNA. RNA polymerase is a prominent nonhistone protein
TLS Online TPP Program

#Id: 428

#Unit 2. Cellular Organization

Individual nucleosomes can be obtained by treating chromatin with the endonuclease micrococcal nuclease (MNase), which cuts the DNA between nucleosomes, a region known as linker DNA.
TLS Online TPP Program

#Id: 429

#Unit 2. Cellular Organization

Mononucleosomes typically have 200 bp DNA. End-trimming reduces the length of DNA first to 165 bp and then generates core particles with 146 bp.
TLS Online TPP Program

#Id: 430

#Unit 2. Cellular Organization

Mnase digestion result on centrifugation and electrophoresis
TLS Online TPP Program

#Id: 431

#Unit 2. Cellular Organization

Core DNA has an invariant length of 146 bp the minimum length of DNA needed to form a stable monomeric nucleosome, and is relatively resistant to digestion by nucleases.