Autophagy occurs in the following sequence of steps:

Induction by activation of mTOR complex 1

• Nucleation of autophagosome formation by ATG9

• Closure of the membrane cup to form autophagosome

• Fusion of the autophagosome with lysosomes, catalyzed by SNAREs.

• Digestion of the inner membrane and the lumenal contents of the autophagosome

TLS Online TPP Program

#Id: 1483

#Unit 4. Cell Communication and Cell Signaling

MYC is translocated close to an antibody gene, leading to overproduction of MYC IN Burkitt’s Lymphoma due to translocation from Chromosome 8 to 14.

TLS Online TPP Program

#Id: 1484

#Unit 4. Cell Communication and Cell Signaling

Monomers and dimers of p53, exists in the cytoplasm. 

TLS Online TPP Program

#Id: 1485

#Unit 4. Cell Communication and Cell Signaling

The tetramerized p53 localize in nucleus for transcriptional activation.

TLS Online TPP Program

#Id: 1486

#Unit 4. Cell Communication and Cell Signaling

When DNA is damaged, p53 is tetramerized and accumulates rapidly.

TLS Online TPP Program

#Id: 1487

#Unit 4. Cell Communication and Cell Signaling

The tumor suppressor proteins p53 and Rb act as guardians of the cell cycle.

TLS Online TPP Program

#Id: 1488

#Unit 4. Cell Communication and Cell Signaling

The DNA damage checkpoint controlled by p53.