The M6P receptor protein binds to M6P at pH 6.5–6.7 in the TGN lumen and releases it at pH 6, in the lumen of endosomes.

TLS Online TPP Program

#Id: 1021

#Unit 5. Developmental Biology

The vertebrate ectoderm, has 3 major responsibilities:

1. One part will become the neural plate

2. One part will become the epidermis

3. One part will become the neural crest

TLS Online TPP Program

#Id: 1022

#Unit 5. Developmental Biology

High levels of BMP specify the cells to become epidermis.

TLS Online TPP Program

#Id: 1023

#Unit 5. Developmental Biology

Very low levels of BMP specify the cells to become neural plate.

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#Id: 1024

#Unit 5. Developmental Biology

Intermediate levels of BMP effect the formation of the neural crest cells.

TLS Online TPP Program

#Id: 1025

#Unit 5. Developmental Biology

In mammals, Noggin (antagonist of BMP) is expressed in the notochord and neural folds.

TLS Online TPP Program

#Id: 1026

#Unit 5. Developmental Biology

Neural plate formation follow the principle of development:  often the signals promoting the specification of one cell type also block the specification of an alternative cell type.