The dissolution of nonpolar molecules in water is unfavourable because of the large decrease in entropy resulting from clathrate formation, even though the process is exothermic (dH < 0) But unfavourable dG > 0.

  

TLS Online TPP Program

#Id: 10459

#Unit 4. Cell Communication and Cell Signaling

Inappropriate production of nuclear transcription factors such as FOS, JUN, and MYC can induce transformation.

TLS Online TPP Program

#Id: 10460

#Unit 4. Cell Communication and Cell Signaling

Burkitt’s lymphoma

translocation between chromosomes 8 and 14

TLS Online TPP Program

#Id: 10461

#Unit 4. Cell Communication and Cell Signaling

In Burkitt’s lymphoma cells, 

MYC is translocated close to an antibody gene, leading to overproduction of MYC

TLS Online TPP Program

#Id: 10462

#Unit 4. Cell Communication and Cell Signaling

MYC gene encodes a basic helix-loop-helix protein

include MAD, MAX, and MNT

TLS Online TPP Program

#Id: 10463

#Unit 4. Cell Communication and Cell Signaling

MYC-MAX dimers regulate genes that control proliferation, such as cyclins.

TLS Online TPP Program

#Id: 10464

#Unit 4. Cell Communication and Cell Signaling

MAD and MNT work with the SIN3 co-repressor protein to bring in histone deacetylases that help to block transcription