TLS Online TPP Program

#Id: 9969

#Unit 4. Cell Communication and Cell Signaling

Homologs

LRP in vertebrates = Arrow in Drosophila

TLS Online TPP Program

#Id: 9970

#Unit 4. Cell Communication and Cell Signaling

In the absence of Wnts,

“free” β-catenin are targeted for degradation by a cytosolic destruction complex that is held together by the tumor suppressor protein Axin.

TLS Online TPP Program

#Id: 9971

#Unit 4. Cell Communication and Cell Signaling

β-catenin Destruction Complex contains:

Tumor suppressor APC

Dvl protein

Constitutively active protein kinases GSK 3β and CK1

TLS Online TPP Program

#Id: 9972

#Unit 4. Cell Communication and Cell Signaling

Kinases CK1 and GSK3,

sequentially phosphorylate β-catenin at multiple serine and threonine residues

TLS Online TPP Program

#Id: 9973

#Unit 4. Cell Communication and Cell Signaling

E3 βTrCP ubiquitin ligase then binds to two phosphorylated residues on β catenin, leading to ubiquitinylation and degradation in proteasomes.

TLS Online TPP Program

#Id: 9974

#Unit 4. Cell Communication and Cell Signaling

In the absence of Wnt,

TCF is associated with transcriptional repressor proteins Groucho (Gro) that inhibit gene transcription in nucleus