Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase

TLS Online TPP Program

#Id: 7500

#Unit 4. Cell Communication and Cell Signaling

Light-chain recombination occurs at the small pre-B-cell stage of B-cell development.

TLS Online TPP Program

#Id: 7501

#Unit 4. Cell Communication and Cell Signaling

Site of DNA cleavage - Recombination Signal Sequence (RSS) 

TLS Online TPP Program

#Id: 7502

#Unit 4. Cell Communication and Cell Signaling

Recognition of Recombination Signal Sequence (RSS) by the RAG1/RAG2 enzyme complex.

TLS Online TPP Program

#Id: 7503

#Unit 4. Cell Communication and Cell Signaling

RAG1 is expressed at all phases of the cell cycle, RAG2 is stable only in G0- or G1-phase cells.

TLS Online TPP Program

#Id: 7504

#Unit 4. Cell Communication and Cell Signaling

Threonine residue T490 on RAG2 is phosphorylated during the S, G2, and M phases of the cell cycle, and this phosphorylation triggers the destruction of RAG2. 

TLS Online TPP Program

#Id: 7505

#Unit 4. Cell Communication and Cell Signaling

RAG1 is the predominant recombinase; it forms a complex with the RSS that is stabilized by the binding of RAG2. RAG2 by itself does not exhibit detectable RSS binding activity