One NPF is called WASp, as it is defective in patients with Wiskott-Aldrich syndrome.

TLS Online TPP Program

#Id: 8905

#Unit 2. Cellular Organization

Most of the cohesins along the chromosome arms are removed from chromosomes during prophase, mediated by phosphorylation of cohesins by Plk1 & Aurora B kinase.

TLS Online TPP Program

#Id: 8906

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8907

#Unit 2. Cellular Organization

Centromere associated cohesins are specifically protected from phosphorylation dependent removal by protein phosphatase 2A

TLS Online TPP Program

#Id: 8908

#Unit 2. Cellular Organization

Phosphatase is recruited to centromeric by the Shugoshin family of proteins

TLS Online TPP Program

#Id: 8909

#Unit 2. Cellular Organization

Separase cleaves centromeric cohesin, triggering the onset of anaphase, releasing the sister chromatids

TLS Online TPP Program

#Id: 8910

#Unit 2. Cellular Organization

Before anaphase Separase is inhibited by the binding of the protein securin and Mitotic CDKs.