When the Ca2+ level rises, Ca2+ binds CaM.

TLS Online TPP Program

#Id: 3369

#Unit 3. Fundamental Processes

DinB and UmuC are members of a distinct family of DNA polymerases found in many organisms known as the Y family of DNA polymerases. There are five translesion polymerases known in humans, four of which belong to the Y family.

TLS Online TPP Program

#Id: 3370

#Unit 3. Fundamental Processes

A human member of the Y family of translesion polymerases (DNA Pol h) correctly inserts two A residues opposite a thymine dimer. 

TLS Online TPP Program

#Id: 3371

#Unit 3. Fundamental Processes

Structural studies show that the active site of DNA Pol h is better at accommodating a thymine dimer than is the active site of another translesion DNA polymerase (DNA Pol k

TLS Online TPP Program

#Id: 3374

#Unit 3. Fundamental Processes

Translesion synthesis replicates across the DNA lesion, but the lesion remains in the genome until a DNA repair pathway can subsequently correct the damage.

TLS Online TPP Program

#Id: 3393

#Unit 3. Fundamental Processes

Because of its high error rate, translesion synthesis (like NHEJ) can be considered a system of last resort. It enables the cell to survive what might otherwise be a catastrophic block to replication, but the price that is paid is a higher level of mut

TLS Online TPP Program

#Id: 3396

#Unit 3. Fundamental Processes

The genes encoding the translesion polymerases are expressed as part of a pathway known as the SOS response.