Co and N atoms of the peptide grouping are both in planar sp2 hybridization and the Co and O atoms are linked by a p bond, leaving the nitrogen with a lone pair of electrons in a 2p orbital.

TLS Online TPP Program

#Id: 5995

#Unit 3. Fundamental Processes

From the speed of replication, it is evident that a mammalian genome could be replicated in 1 hour if all replicons functioned simultaneously. S phase actually lasts for 6 hours in a typical somatic cell, though, which implies that no more than 15% of the replicons are likely to be active at any given moment.

TLS Online TPP Program

#Id: 5996

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 5997

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 5998

#Unit 3. Fundamental Processes

An ARS element consists of an A-T–rich region that contains discrete sites in which mutations affect origin function.

TLS Online TPP Program

#Id: 5999

#Unit 3. Fundamental Processes

A 14-bp “core” region, called the A domain, which contains an 11-bp consensus sequence consisting of A-T base pairs. This consensus sequence (sometimes called the ACS, for ARS)

TLS Online TPP Program

#Id: 6000

#Unit 3. Fundamental Processes

The origin recognition complex (ORC) is a highly conserved complex found in all eukaryotes.  It is composed of six proteins with a mass of 400 kD.  ORC binds to the yeast A and B1 elements on the A-T–rich strand and is associated with ARS elements throughout the cell cycle.