Domain

Domains are formed by combinations of SS, SSS, motifs and connected by loops and turns.

Highly conversed and may be common in most unrelated proteins

They evolve

Can function Independently

Average 100 amino acids 

Single hydrophobic core

TLS Online TPP Program

#Id: 10002

#Unit 4. Cell Communication and Cell Signaling

Desert hedgehog protein is found in the Sertoli cells of the testes

TLS Online TPP Program

#Id: 10003

#Unit 4. Cell Communication and Cell Signaling

Mice homozygous for a null allele of dhh exhibit defective spermatogenesis

TLS Online TPP Program

#Id: 10004

#Unit 4. Cell Communication and Cell Signaling

Indian hedgehog is expressed in the gut and cartilage and is important in postnatal bone growth

TLS Online TPP Program

#Id: 10005

#Unit 4. Cell Communication and Cell Signaling

Sonic hedgehog is responsible for assuring that motor neurons come only from the ventral portion of the neural tube & essential for normal patterning of the limbs

TLS Online TPP Program

#Id: 10006

#Unit 4. Cell Communication and Cell Signaling

Hedgehog protein with autoproteolytic activity that cleaves off the C-terminus to reveal a signal sequence that marks the protein for secretion.

TLS Online TPP Program

#Id: 10007

#Unit 4. Cell Communication and Cell Signaling