B-type lamins - expressed in essentially all cells (primordial lamin proteins)

lamins A and C - developmentally regulated

TLS Online TPP Program

#Id: 9918

#Unit 4. Cell Communication and Cell Signaling

Innate response elements commonly engaged by encounter with viral PAMPs, such as secretion of type I interferons, inflammasome and NK-cell activation, as well as IL-12 production.

TLS Online TPP Program

#Id: 9919

#Unit 4. Cell Communication and Cell Signaling

Mechanisms of humoral and cell-mediated immune responses

TLS Online TPP Program

#Id: 9920

#Unit 4. Cell Communication and Cell Signaling

Many Viruses Are Neutralized by Antibodies

Antibodies are particularly effective if they are localized at the site of viral entry into the body.

TLS Online TPP Program

#Id: 9921

#Unit 4. Cell Communication and Cell Signaling

Cell-Mediated Immunity against Virus

Both CD8+ TC cells and CD4+ TH1 cells are required components of the cell-mediated antiviral defense.

Activated TH1 cells produce IL-2, IFN-ϒ, and tumor necrosis factor-α.

TLS Online TPP Program

#Id: 9922

#Unit 4. Cell Communication and Cell Signaling

IFN-ϒ acts directly by inducing an antiviral state in nearby cells.

IL-2 acts indirectly by assisting the development of cytotoxic T lymphocyte(CTL) precursors into an effector population.

Both IL-2 and IFN-ϒ activate NK cells.

TLS Online TPP Program

#Id: 9923

#Unit 4. Cell Communication and Cell Signaling