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TLS Online TPP Program

#Id: 8755

Thermodynamic measurements indicate that native proteins are only marginally stable under physiological conditions. The free energy required to denature them is ∼0.4 kJ ∙ mol−1 per amino acid residue.

#Unit 1. Structure and Function of Biomolecules #Protein Stability & Folding #Part B Pointers
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TLS Online TPP Program

#Id: 8193

#Unit 2. Cellular Organization

Pex5 forms a multimeric complex with the Pex14 receptor located on the peroxisomal membrane. 
TLS Online TPP Program

#Id: 8194

#Unit 2. Cellular Organization

After assembly of the matrix protein-Pex5-Pex14 complex, the matrix protein dissociates from Pex5 and is released into the peroxisomal matrix.
TLS Online TPP Program

#Id: 8195

#Unit 2. Cellular Organization

A Pex 2, Pex 10, and Pex 12 complex embedded in the peroxisomal membrane transfers Ubiquitin to two embedded Pex 5 receptors.
TLS Online TPP Program

#Id: 8196

#Unit 2. Cellular Organization

The AAA ATPases Pex1 and Pex6 complex use the energy from ATP hydrolysis and causing the detachment of Pex 5 receptors into cytosol.
TLS Online TPP Program

#Id: 8197

#Unit 2. Cellular Organization

Zellweger syndrome
Autosomal recessive Mutations in any of a dozen different peroxins, the most common being Pex1, cause an impairment in peroxisomal protein import.
TLS Online TPP Program

#Id: 8198

#Unit 2. Cellular Organization

Lysosomes are membrane-enclosed organelles filled with soluble hydrolytic enzymes that digest macromolecules.