TLS Online TPP Program

#Id: 6575

#Unit 7. System Physiology – Animal

The Y chromosome is necessary and sufficient for the production of testes, and the testis-determining gene product is called SRY (for sex-determining region of the Y chromosome)

TLS Online TPP Program

#Id: 6576

#Unit 7. System Physiology – Animal

SRY is a DNA-binding regulatory Protein, bends the DNA & acts as a transcription factor that initiates transcription of a cascade of genes necessary for testicular differentiation

TLS Online TPP Program

#Id: 6577

#Unit 7. System Physiology – Animal

When the embryo has functional testes, Leydig cells of the fetal testis secrete testosterone, and the Sertoli cells secrete MIS (MRF)

TLS Online TPP Program

#Id: 6578

#Unit 7. System Physiology – Animal

MIS is a 536-amino-acid homodimer a member of the TGF-β superfamily

TLS Online TPP Program

#Id: 6579

#Unit 7. System Physiology – Animal

MIS causes regression of the müllerian ducts

TLS Online TPP Program

#Id: 6580

#Unit 7. System Physiology – Animal

The walls of the seminiferous tubules are lined by primitive germ cells and Sertoli cells, large, complex glycogen- containing cells that stretch from the basal lamina of the tubule to the lumen