The genetic diseases caused by trinucleotide repeat SSRs within genes. Huntington disease (HD) is one of the approximately 20 such trinucleotide repeat diseases in humans. HD is transmitted as an autosomal dominant mutation.

TLS Online TPP Program

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#Unit 2. Cellular Organization

H2AX subtype is has a C-terminal tail that is distinct from the canonical H2A, characterized by a SQEL/Y motif at the end.

TLS Online TPP Program

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#Unit 2. Cellular Organization

SQEL/Y motif of H2AX is phosphorylated by ATM/ATR kinases, activated by DNA damage, is involved in DNA repair

TLS Online TPP Program

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#Unit 2. Cellular Organization

H2AX phosphorylated at the SQEL/Y motif is sometimes referred to as “gamma-H2AX,”

TLS Online TPP Program

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#Unit 2. Cellular Organization

Gamma-H2AX frequently functions in DSBR

TLS Online TPP Program

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#Unit 2. Cellular Organization

H2AZ variant has 60% sequence identity with canonical H2A and involved in gene activation, heterochromatin–euchromatin boundary formation, cell-cycle progression.

TLS Online TPP Program

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#Unit 2. Cellular Organization

Mammalian macroH2A is enriched in the inactive X chromosome in females, which is assembled into a silent, heterochromatic state