Geminin is expressed in late G1; it binds to and inhibits Cdt1 preventing reloading of the MCM helicase.

TLS Online TPP Program

#Id: 8382

#Unit 2. Cellular Organization

Myosin V

Two heads but does not assemble into filaments

Large and processive

Function- Organelle transport

TLS Online TPP Program

#Id: 8383

#Unit 2. Cellular Organization

All Myosins move toward the (+) end of an actin filament except myosin VI. Myosin VI move toward the (−) end of an actin filament

TLS Online TPP Program

#Id: 8384

#Unit 2. Cellular Organization

The length of the myosin II neck domain determines the rate of movement.

TLS Online TPP Program

#Id: 8385

#Unit 2. Cellular Organization

In the absence of ATP, the myosin head is firmly attached to the actin filament. 

TLS Online TPP Program

#Id: 8386

#Unit 2. Cellular Organization

In the presence of ATP,  myosin head releases from the actin filament. 

TLS Online TPP Program

#Id: 8387

#Unit 2. Cellular Organization

Thick-filament regulation

Myosin-dependent mechanism regulate contraction in smooth muscle and non-muscle cells.