TLS Online TPP Program

#Id: 706

#Unit 3. Fundamental Processes

Repair Systems such as MMR reduces error rate of replication to 10-9 per base pair replicated

TLS Online TPP Program

#Id: 707

#Unit 3. Fundamental Processes

SeqA binds to hemimethylated DNA and is required for delaying rereplication.

TLS Online TPP Program

#Id: 708

#Unit 3. Fundamental Processes

seqA is part of a negative regulatory circuit that prevents origins from being remethylated.

TLS Online TPP Program

#Id: 709

#Unit 3. Fundamental Processes

A locus called dat has a large concentration of DnaA-binding sites. It binds about 80 more DnaA molecules than the origin.

TLS Online TPP Program

#Id: 710

#Unit 3. Fundamental Processes

Deletion of dat causes initiation to occur more frequently. This significantly increases the amount of DnaA available to the origin

TLS Online TPP Program

#Id: 711

#Unit 3. Fundamental Processes

DnaA has a weak intrinsic activity that converts the ATP to ADP, this is enhanced by a factor termed Hda.