Nurturing Life Sciences
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#Unit 4. Cell Communication and Cell Signaling
SOCS-1, binds to the critical phosphotyrosine in the activation loop of an activated JAK2 kinase, inhibiting its catalytic activity
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The cytosolic domain of RTKs contains an intrinsic protein tyrosine kinase domain.
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Cytosolic kinase domain of an RTK contains a flexible domain termed activation loop.