Centralspindlin is a heterotetramer composed of two copies of the kinesin-6 motor protein MKLP1 and a dimer of a Rho GAP

TLS Online TPP Program

#Id: 4754

#Unit 5. Developmental Biology

The determination of the P1-derived somatic founder cells (MS, E, C, and D)are autonomous, with cell fates determined by internal cytoplasmic factors SKN-1, PAL-1, and PIE-1

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#Id: 4755

#Unit 5. Developmental Biology

The SKN-1 protein is a transcription factor that initiates the activation of those genes responsible for forming the pharynx and intestine.

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#Id: 4756

#Unit 5. Developmental Biology

The SKN-1 protein is a maternally expressed transcription factor that controls the fate of the P1 blastomere(P1🡪EMS 🡪MS), that generates the posterior pharynx.

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#Id: 4757

#Unit 5. Developmental Biology

Embryos from homozygous skn-1-deficient mothers lack both pharyngeal mesoderm & endoderm derivatives of EMS.

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#Id: 4758

#Unit 5. Developmental Biology

skn-1-deficient embryos make extra hypodermal (skin) & body wall tissue.

TLS Online TPP Program

#Id: 4759

#Unit 5. Developmental Biology

PAL-1 activity is needed for the normal development of the somatic (but not the germline) descendants of the P2 blastomere, specifies muscle production.