MKLP1 is inhibited by 14-3-3 to ensures that the spindle midzone microtubules do not compact until the end of anaphase

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#Id: 95

#Unit 5. Developmental Biology

Cytoplasmic Determinants

Blastomeres of the early embryo are apportioned a set of critical determination factors within the egg cytoplasm that determine cell fate

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#Id: 96

#Unit 5. Developmental Biology

Cytoplasmic Determinants are molecules, often transcription factors that regulate gene expression that directs the cell along a particular path of maturation.

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#Id: 97

#Unit 5. Developmental Biology

Conditional specification is the process by which cells achieve their respective fates by interacting with other cells.

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#Id: 98

#Unit 5. Developmental Biology

In conditional specification the array of interactions it has with its neighbors, which may include: 

cell-to-cell contacts (juxtacrine factors)

secreted signals (paracrine factors)

physical properties of its local environment (mechanical stress)

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#Id: 99

#Unit 5. Developmental Biology

In Conditional Specification

Prospective potency is greater than prospective fate.

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#Id: 100

#Unit 5. Developmental Biology

Massive cell rearrangements and migrations precede or accompany conditional specification.