No matter how it is born, a new gene starts its life as a single copy in the population.

As with any new mutation, by far the most likely outcome is that it will be lost by random drift or selection over the next few generations

TLS Online TPP Program

#Id: 1422

#Unit 4. Cell Communication and Cell Signaling

Fibronectin binds to integrin through an RGD motif.

TLS Online TPP Program

#Id: 1423

#Unit 4. Cell Communication and Cell Signaling

The binding of integrins to their ligands depends on extracellular divalent cations(Ca+2 & Mg+2).

TLS Online TPP Program

#Id: 1424

#Unit 4. Cell Communication and Cell Signaling

The α subunit of each integrin is the primary determinant of its extracellular ligand specificity.

TLS Online TPP Program

#Id: 1425

#Unit 4. Cell Communication and Cell Signaling

Several integrin α subunits contain, I-domain, which can mediate binding of integrins to various collagens in the ECM.

TLS Online TPP Program

#Id: 1426

#Unit 4. Cell Communication and Cell Signaling

I-domains also recognize CAMs on other cells,  ICAMs, VCAMs and participate in cell-cell adhesion.

TLS Online TPP Program

#Id: 1427

#Unit 4. Cell Communication and Cell Signaling

The non-I-domain α subunits recognize RGD motif.