Nurturing Life Sciences
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#Unit 3. Fundamental Processes
Proofreading typically decreases the error rate in replication from10-5 to 10-7 per base pair replicated.
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Repair Systems such as MMR reduces error rate of replication to 10-9 per base pair replicated
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seqA is part of a negative regulatory circuit that prevents origins from being remethylated.
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A locus called dat has a large concentration of DnaA-binding sites. It binds about 80 more DnaA molecules than the origin.
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Deletion of dat causes initiation to occur more frequently. This significantly increases the amount of DnaA available to the origin