TLS Online TPP Program

#Id: 6215

#Unit 12. Applied Biology

These vectors are advantageous in that they can deliver many genome copies per host cell and so typically are associated with high expression. 

TLS Online TPP Program

#Id: 4018

#Unit 7. System Physiology – Animal

When the potential reaches a threshold voltage of about −40 millivolts, the L-type calcium channels become “activated,” causing the action potential

TLS Online TPP Program

#Id: 6978

#Unit 8. Inheritance Biology

HUMAN TRISOMIES

Trisomy 18 - Edward syndrome

Trisomy 13 - Patau syndrome. 

TLS Online TPP Program

#Id: 7075

#Unit 3. Fundamental Processes

isoleucyl-tRNA synthetase has a nearby editing pocket (a deep cleft in the enzyme) that allows it to proofread the product of the adenylylation reaction. AMP-valine (as well as adenylylates of other small amino acids, such as alanine) can fit into this editing pocket, where it is hydrolyzed and released as free valine and AMP. In contrast, AMP-isoleucine is too large to enter the editing pocket and is therefore not subject to hydrolysis. As a consequence, isoleucyl-tRNA synthetase discriminates against valine twice: in the initial binding and adenylylation of the amino acid (discriminating by a factor of 100), and then in the editing of the adenylylated amino acid (again discriminating by a factor of 100), for an

overall selectivity of 10,000-fold (i.e., an error rate of 0.01%).

TLS Online TPP Program

#Id: 10531

#Unit 4. Cell Communication and Cell Signaling