Inactive PKA is a tetramer consisting of- 

two regulatory (R) subunits

two catalytic (C) subunits

TLS Online TPP Program

#Id: 2661

#Unit 7. System Physiology – Animal

Thick ascending limb is called the diluting segment because NaCl is reabsorbed but water is not reabsorbed along with it.

TLS Online TPP Program

#Id: 2662

#Unit 7. System Physiology – Animal

The tubular fluid that leaves the thick ascending limb has a lower Na+ concentration and a lower osmolarity than blood.

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#Id: 2663

#Unit 7. System Physiology – Animal

Recycling of K+ 

Most, but not all, of the K+ that enters the cell through cotransporter leaves the cell across BM, A portion of the K+, diffuses back into the lumen.

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#Id: 2664

#Unit 7. System Physiology – Animal

The thick ascending limb of the loop of Henle is the site of action of the powerful “loop” diuretics.

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#Id: 2665

#Unit 7. System Physiology – Animal

“Loop” Diuretics are:

Furosemide

Ethacrynic acid

Bumetanide 

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#Id: 2666

#Unit 7. System Physiology – Animal

“Loop” diuretics, inhibits 1-sodium, 2-chloride, 1-potassium 

co-transporter.