Pertussis toxin, produced by Bordetella pertussis, catalyzes ADP-ribosylation of the  subunit of Gαi, preventing GDP-GTP exchange and blocking inhibition of adenylyl cyclase.

TLS Online TPP Program

#Id: 415

#Unit 2. Cellular Organization

SQEL/Y motif of H2AX is phosphorylated by ATM/ATR kinases, activated by DNA damage, is involved in DNA repair

TLS Online TPP Program

#Id: 416

#Unit 2. Cellular Organization

H2AX phosphorylated at the SQEL/Y motif is sometimes referred to as “gamma-H2AX,”

TLS Online TPP Program

#Id: 417

#Unit 2. Cellular Organization

Gamma-H2AX frequently functions in DSBR

TLS Online TPP Program

#Id: 418

#Unit 2. Cellular Organization

H2AZ variant has 60% sequence identity with canonical H2A and involved in gene activation, heterochromatin–euchromatin boundary formation, cell-cycle progression.

TLS Online TPP Program

#Id: 419

#Unit 2. Cellular Organization

Mammalian macroH2A is enriched in the inactive X chromosome in females, which is assembled into a silent, heterochromatic state

TLS Online TPP Program

#Id: 420

#Unit 2. Cellular Organization

Mammalian H2ABbd variant is excluded from the inactive X and forms a less stable nucleosome than canonical H2A