IP3 triggers the opening of IP3-gated Ca²+ channels in the ER and elevation of cytosolic free Ca²+.

TLS Online TPP Program

#Id: 10075

#Unit 4. Cell Communication and Cell Signaling

In cultured cells, C → Y mutation in the EC5 domain of CDHR3 increases the cell-surface expression of CDHR3 and the binding and replication of RV-C.

TLS Online TPP Program

#Id: 10076

#Unit 4. Cell Communication and Cell Signaling

Integrins are the principal receptors used by animal cells to bind to the extracellular matrix. 

TLS Online TPP Program

#Id: 10077

#Unit 4. Cell Communication and Cell Signaling

An integrin molecule is composed of two noncovalently associated transmembrane glycoprotein subunits called α and β.

TLS Online TPP Program

#Id: 10078

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10079

#Unit 4. Cell Communication and Cell Signaling

Integrins function as transmembrane linkers (integrators) between the extracellular matrix and the actin cytoskeleton.

TLS Online TPP Program

#Id: 10080

#Unit 4. Cell Communication and Cell Signaling

Integrins bind extracellular matrix (ECM) glycoproteins, 

1. Laminins  

2. Collagens 

3. Fibronectin

4. Vitronectin