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TLS Online TPP Program

#Id: 9479

SOCS-1, binds to the critical phosphotyrosine in the activation loop of an activated JAK2 kinase, inhibiting its catalytic activity

#Unit 4. Cell Communication and Cell Signaling #Cytokine Receptors & JAK/STAT Signaling Pathway #Part B Pointers
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TLS Online TPP Program

#Id: 10414

#Unit 4. Cell Communication and Cell Signaling

Growth factors that stimulate angiogenesis:
Basic fibroblast growth factor, TGF-α, and VEGF
TLS Online TPP Program

#Id: 10415

#Unit 4. Cell Communication and Cell Signaling

Hypoxia-inducible factor 1 (HIF-1) induces transcription of the VEGF gene
TLS Online TPP Program

#Id: 10416

#Unit 4. Cell Communication and Cell Signaling

Prolyl hydroxylase 
active at normal O2 levels, Hydroxylation of HIF-1 causes ubiquitinylation and degradation
TLS Online TPP Program

#Id: 10417

#Unit 4. Cell Communication and Cell Signaling

Metastasis
Spread of cancer cells from their site of origin and establishment of areas of secondary growth
TLS Online TPP Program

#Id: 10418

#Unit 4. Cell Communication and Cell Signaling

Metastasis
cancer cells have acquired the ability to penetrate basement membranes using a cell protrusion called an invadopodium
TLS Online TPP Program

#Id: 10419

#Unit 4. Cell Communication and Cell Signaling

Epithelial-to-mesenchymal transition (EMT) 
play a crucial role in metastasis