SOCS-1, binds to the critical phosphotyrosine in the activation loop of an activated JAK2 kinase, inhibiting its catalytic activity

TLS Online TPP Program

#Id: 1726

#Unit 4. Cell Communication and Cell Signaling

When membrane-bound CD23 binds to soluble IgE, further IgE synthesis is suppressed.

TLS Online TPP Program

#Id: 1727

#Unit 4. Cell Communication and Cell Signaling

FcεRIIB, bear immuno-receptor tyrosine inhibitory motifs Cross-linking of these receptors leads to inhibition, rather than to activation of cellular responses.

TLS Online TPP Program

#Id: 1728

#Unit 4. Cell Communication and Cell Signaling

If an allergen binds both IgG and IgE molecules, it will trigger signals through both Fc receptors. The inhibitory signal dominates.

TLS Online TPP Program

#Id: 1729

#Unit 4. Cell Communication and Cell Signaling

FcεRI pathways are phosphorylations, multiple phosphatases, such as SHPs, SHIPs, and PTEN, play an important role in dampening receptor signaling.

TLS Online TPP Program

#Id: 1730

#Unit 4. Cell Communication and Cell Signaling

Lyn, can play a negative as well as a positive role in FcεRI signaling by phosphorylating and activating the inhibitory FcεRIIB.

TLS Online TPP Program

#Id: 1731

#Unit 4. Cell Communication and Cell Signaling

FcεRI signalling through Lyn and Syk kinases also activates E3 ubiquitin ligases, including c-Cbl. Cbl ubiquitinylates Lyn and Syk, as well as FcεRI itself, triggering their degradation.