Late blight disease (A), caused by the oomycete pathogen Phytophthora infestans

Black stem rust, which results from infection by the basidiomycete Puccinia graminis

Global banana (Musa spp.) production is under threat from black Sigatoka disease Mycosphaerella fijiensis.

TLS Online TPP Program

#Id: 8343

#Unit 2. Cellular Organization

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly

TLS Online TPP Program

#Id: 8345

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8346

#Unit 2. Cellular Organization

Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase

TLS Online TPP Program

#Id: 8347

#Unit 2. Cellular Organization

To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)

TLS Online TPP Program

#Id: 8348

#Unit 2. Cellular Organization

The major NPF family is characterized by the presence of a region called WCA (WH2, connector, acidic)

TLS Online TPP Program

#Id: 8349

#Unit 2. Cellular Organization