In maize (Zea mays) leaves, the HC toxin inhibits histone deacetylases to effect changes in host gene expression, presumably those genes involved in defense against C. carbonum.

TLS Online TPP Program

#Id: 1497

#Unit 4. Cell Communication and Cell Signaling

P53 turned on GADD45 to stimulate DNA repair.

TLS Online TPP Program

#Id: 1498

#Unit 4. Cell Communication and Cell Signaling

P53 turned on  p2I/WAF-I, which binds to and inhibits the CDK/cyclin complexes for GI arrest

TLS Online TPP Program

#Id: 1499

#Unit 4. Cell Communication and Cell Signaling

P53 turned on sets of large intergenic noncoding RNAs to mediate transcription repression; and miRNAs.

TLS Online TPP Program

#Id: 1500

#Unit 4. Cell Communication and Cell Signaling

p2I -IincRNA, mediates the repressive properties of p53 by binding to specific chromatin complexes.

TLS Online TPP Program

#Id: 1501

#Unit 4. Cell Communication and Cell Signaling

The amyloid aggregation of p53 lose its suppressor function and acquire oncogenic function.

 

TLS Online TPP Program

#Id: 1502

#Unit 4. Cell Communication and Cell Signaling

p53 amyloid aggregates,

No transport from cytoplasm to the nucleus

Escape proteasome degradation